JZL-184 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate

BML-EI391-0010 EI391-0050

89158-254EA 185.98 CAD

89158-254 89158-256

JZL-184 ≥98% (by TLC)

JZL-184

Potent, selective and irreversible inhibitor of MAG lipase (IC50=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.

Monoacylglycerol lipase inhibitor

Off-white solid.

Soluble in DMSO (10mg/ml).

Formula: C₂₇H₂₄N₂O₉
MW: 520.5
Storage Temperature: Ambient

CAS Number: 1101854-58-3

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