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Latrunculin B ≥98% (by TLC)

Supplier: Enzo Life Sciences

Ultra-pure; inhibits actin polymerization

Structurally unique marine toxin. Actin filament modulator. 10- to 100-fold more potent than cytochalasins. Whereas cytochalasin D (Prod. No. BML-T109) induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers. Effects on N1E-115 cells (mouse neuroblastoma) at concentrations as low as 90nM (NI43T3 cells, 0.9µM). Maximum effects at 2.5µM. Slowly inactivated by fetal bovine serum. Inhibition of cofilin-actin binding (ED50~50µM)

Isolated from Latrunculia magnifica.

Formula: C₂₀H₂₉NO₅S
MW: 395.514 g/mol
CAS Number: 76343-94-7



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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg BML-T110-0001 89164-972 Each Retrieving Restricted

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