The mammalian Kruppel-like transcription factor, KLF4 is involved in preventing centrosome amplification following DNA damage caused by gamma-irradiation. It is both necessary and sufficient in preventing centrosome amplification following gamma-radiation-induced DNA damage and does so by transcriptionally suppressing cyclin E expression n. Kruppel-like factor 4 is also known to exhibit checkpoint function during the G1/S and G2/M transitions of the cell cycle.
KLF4 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 ?g/mL.
Protein A Column
PBS, 2% sucrose.
Aliquot and store at -20°C. Avoid multiple freeze-thaw cycles.
Type:
Antigen: KLF4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human