Anti-AURKA Rabbit Polyclonal Antibody

10074-422EA 776.14 CAD
Anti-AURKA Rabbit Polyclonal Antibody
ARK1, an Aurora/IPL1-like protein kinase, functions in centrosome separation, duplication, and maturation and in bipolar spindle assembly and stability. The protein has been shown to localize to centrosomes in S phase as soon as centrioles have been duplicated, and to be degraded in early G1. ARK1 phosphorylation is induced by okadaic acid treatment in vivo. Activated ARK1 has been shown to phosphorylate the spindle apparatus-associated protein, TPX2, and it is believed to be targeted to the spindle apparatus by this protein. At least three alternative splice forms have been reported; however, the alternative splice sites are located in the 5’-untranslated region and appear to have no effect on protein translation. ARK1 has been identified as an oncogene that is overexpressed in several types of solid tumors and tumor cell lines, including those from breast and colon. Additionally, overexpression of ARK1 has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy, and genomic instability.

Aurora-Related Kinase 1 antibody can be used in ELISA, and immunohistochemistry starting at 10 ?g/mL.

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Antigen: AURKA
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR