PLK, a Polo type protein kinase, has been shown to function in mitosis. The mRNA is absent or expressed at very low levels during the G1 phase, begins to reaccumulate during the S phase, and reaches maximal levels during the G2/M phase. PLK1 may participate in targeting MPF to the nucleus during prophase and in regulating mitotic spindle function. These functions, in addition to its expression in proliferating cells, suggest that PLK1 has a role in cancer progression.
Polo-Like Kinase antibody can be used in Western Blot starting at 2 ?g/mL, immunohistochemistry starting at 10 ?g/mL, and flow cytometry.
Affinity Chromatography
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml.
Aliquot and store at 4ºC. Avoid freezing.
Type: Primary
Antigen: PLK1
Clonality: Monoclonal
Clone: [2A3]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human