Anti-NR1I2 Rabbit Polyclonal Antibody

49-122
10078-608EA 623.55 CAD
10078-608
Anti-NR1I2 Rabbit Polyclonal Antibody
Pregnane X receptor (PXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to mediate the effects of steroid hormones, including progesterone, glucocorticoid, and pregnenolone, and effects of xenobiotics, through the cytochrome P-450 3A gene family (CYP3A). PXR protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. PXR also has been suggested to regulate drug efflux by activating expression of the MDR1 gene, control the biosynthesis and metabolism of bile acids, and influence the protection of the feto-maternal system from the toxic effects of endogenous steroids and foreign substrates. PXR binds as a heterodimer (with RXR) to the CYP3A promoter region. At least six protein isoforms, produced by alternative splicing, have been reported.

NR1I2 antibody can be used in immunohistochemistry starting at 10 ?g/mL.

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type:
Antigen: NR1I2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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