Anti-SIRT1 Rabbit Polyclonal Antibody

Supplier: ProSci

10078-626EA 1011.8 CAD
Anti-SIRT1 Rabbit Polyclonal Antibody
The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.

SIRT1 antibody can be used in immunohistochemistry starting at 10 ?g/mL.

Affinity Chromatography

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.

Store SIRT1 antibody at 4 °C. Do not freeze.

Type: Primary
Antigen: SIRT1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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