Anti-LTK Rabbit Polyclonal Antibody

Supplier: ProSci

10076-306EA 1011.53 CAD
Anti-LTK Rabbit Polyclonal Antibody
Leukocyte tyrosine kinase (LTK) is a receptor-type protein tyrosine kinase, belonging to the insulin receptor superfamily, and is mainly expressed in B lymphocyte precursors and neuronal tissues. LTK utilizes insulin receptor substrate-1 (IRS-1) and Shc as major two substrates and possesses two NPXY motifs for them separately, tyrosine 485 of one NPXY motif at the juxtamembrane domain for IRS-1 and tyrosine 862 of another NPXY motif at the carboxyl-terminal domain for Shc. It has also been shown that p85 subunit of PI3 kinase directly binds to tyrosine 753 of LTK, which is located within a YXXM motif. Tyrosine 485 and 753 are responsible for IRS-1 and PI3K mediated survival effects of LTK, respectively.

LTK antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 ?g/mL, and immunofluorescence starting at 10 ?g/mL.

Protein G Column

PBS, 0.2% gelatin, 0.05% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: LTK
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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