Anti-TLR4 Mouse Monoclonal Antibody [clone: [76B357.1]]

Supplier: ProSci

49-321
10076-346EA 1011.8 CAD
10076-346
Anti-TLR4 Mouse Monoclonal Antibody [clone: [76B357.1]]
Antibodies
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa. Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

TLR4 antibody can be used in immunohistochemistry starting at 10 ?g/mL.

Protein G Column

PBS, 0.05% BSA, 0.05% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: TLR4
Clonality: Monoclonal
Clone: [76B357.1]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b,k
Reactivity: Human, Mouse, Rat
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