Anti-TNFRSF11B Mouse Monoclonal Antibody [clone: [98A1071]]

Supplier: ProSci

49-329
10076-362EA 1011.8 CAD
10076-362
Anti-TNFRSF11B Mouse Monoclonal Antibody [clone: [98A1071]]
Antibodies
Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor (TNFR) superfamily. As the name implies, it protects bone. Unlike other TNFRs it lacks a transmembrane domain and lacks any apparent cell associated signals. OPG consists of 401 amino acid with molecular mass of approximately 55 kD as a monomer and 110 kD as a disulfide-linked dimer. High levels of OPG mRNA has been detected in lung, heart, kidney, and placenta1. Recombinant OPG blocks osteoclastogenesis in vitro and increases bone density in vivo. Targeted deletion of OPG in mice results in severe early-onset of osteoporosity. These mice also exhibit increase in vascular calcification in the aorta and renal arteries suggesting that it may also play a role in degenerative arterial disease.

TNFRSF11B antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ?g/mL.

Protein G Column

PBS, 0.2% gelatin, 0.05% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: TNFRSF11B
Clonality: Monoclonal
Clone: [98A1071]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Gibbon, Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR