Anti-TNFRSF13B Rabbit Polyclonal Antibody

Supplier: ProSci

10078-816EA 1047.24 CAD
Anti-TNFRSF13B Rabbit Polyclonal Antibody
Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and BlyS (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells. Recently two orphan receptors TACI and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-κB, and AP-1. TACI is one of three know receptors for BLys. Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

TNFRSF13B antibody can be used in Western Blot starting at 1:1000, immunohistochemistry starting at 5 ?g/mL, immunohistochemistry -Pfa starting at 1 ?g/mL, and flow cytometry.

Protein G Column

PBS containing 0.05% sodium azide and 0.2% gelatin.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: TNFRSF13B
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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