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Specifications
- Antibody type:Primary
- Antigen name:ADAM metallopeptidase domain 17
- Clonality:Polyclonal
- Gene ID:P78536
- Host:Rabbit
- Reactivity:Human,Rat,Mouse
- Antigen symbol:ADAM17
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:0.05 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:ADAM17
- Storage buffer:PBS, 0.02% sodium azide.
- Storage temperature:Short term: 4 °C. Long term: Store at –20 °C. Avoid freeze-thaw cycles.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:ADAM17 antibody was raised against amino acids 807-823 from the C-Terminus of ADAM17 (Human).
- Tested applications:Immunoaffinity Chromatography
- Purification:Immunoaffinity Chromatography
- Cat. no.:10076-382
Specifications
About this item
Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease.
- ADAM17 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.
PBS, 0.02% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: ADAM17
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat