Anti-SPRY4 Rabbit Polyclonal Antibody

Supplier: ProSci
10079-114EA 1101.77 CAD
Anti-SPRY4 Rabbit Polyclonal Antibody
Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.

SPRY4 antibody can be used in Western Blot, immunohistochemistry starting at 1:200, and immunoprecipitation.

0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: SPRY4
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Chimpanzee, Human
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