Anti-BAX Mouse Monoclonal Antibody [clone: [6A7]]

49-979
10079-350EA 1011.8 CAD
10079-350
Anti-BAX Mouse Monoclonal Antibody [clone: [6A7]]
Antibodies
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

BAX antibody can be used in Western Blot starting at 1 ?g/mL, and immunohistochemistry starting at 10 ?g/mL.

Affinity Chromatography

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: BAX
Clonality: Monoclonal
Clone: [6A7]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Monkey, Mouse, Rat
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