PSMA (prostate specific membrane antigen) is a type II integral membrane glycoprotein. It is highly expressed in the prostate epithelium, and also expressed in the small intestine, brain, kidney, liver, spleen, colon and the capillary endothelium of a variety of tumors. PSMA is expressed specifically in jejunum brush border membranes. In the brain, PSMA is highly expressed in the ventral striatum and brain stem. PSMA cytosolic isoform is the most abundant form in normal prostate tissue, while the membrane-bound PSMA-1 form is found in primary prostate tumors. Recent evidence has shown that PSMA is also expressed in tumor-associated neovasculature and may become an effective target for monoclonal antibody-based anti-neovasculature therapy. Suitable for use in ELISA, Immunohistochemistry (FFPE), and Western Blot. Other applications not tested. Recognizes human PSMA protein at ~90kD. Reactivity has been confirmed with human prostate cancer LNCap cell lysates.
- PMSA antibody can be used in Western Blot starting at 2 - 4 μg/mL, immunohistochemistry starting at 5 μg/mL, flow cytometry, and neutralization
Protein A Column
PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: FOLH1
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1,k
Reactivity: Human