Anti-CLDN4 Mouse Monoclonal Antibody

51-078
10076-632EA 623.55 CAD
10076-632
Anti-CLDN4 Mouse Monoclonal Antibody
Tight junctions are specialized regions of cell-cell contact that are particularly abundant in luminal epithelial cell sheets. TJ strands on adjacent cells are presumed to interact with each other to form a "molecular gasket" that prevents ions, water and other molecules from leaking between cells and thus, from one side of the sheet to the other. The 20 known claudin proteins are major structural components of tight junctions. Claudin-4 is overexpressed in pancreatic cancer tissues and cell lines. Expression has been localized at junctions of the duct epithelia and acinar cells in rat pancreas 1. Overexpression of claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability. Suitable for use in Immunohistochemistry (FFPE). Other applications not tested. Recognizes human Claudin 4.

Claudin 4 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 ?g/mL.

Purified

PBS, pH 7.4, 1% BSA and 0.1% sodium azide

Store Claudin 4 antibody at 4 °C or -20 °C. As with all antibodies avoid freeze/thaw cycles.

Type:
Antigen: CLDN4
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity:
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