Anti-MYC Mouse Monoclonal Antibody [clone: [9E10]]

51-118
10079-450EA 811.46 CAD
10079-450
Anti-MYC Mouse Monoclonal Antibody [clone: [9E10]]
The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells.

MYC antibody can be used in ELISA, Western Blot starting at 1 ?g/mL, and immunohistochemistry starting at 5 ?g/mL.

Protein G Column

PBS, 15 mM sodium azide, approx., pH 7.4.

Store MYC antibody at 4 °C or -20 °C. As with all antibodies avoid freeze/thaw cycles.

Type: Primary
Antigen: MYC tag
Clonality: Monoclonal
Clone: [9E10]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Chimpanzee, Gorilla, Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR