Anti-CHCHD6 Rabbit Polyclonal AntibodySupplier: Prosci
10062-518EA 716.01 CAD10062-518
Anti-CHCHD6 Rabbit Polyclonal Antibody
CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 ?g/mL.
CHCHD6 Antibody is affinity chromatography purified via peptide column.
CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide.
CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.