Mouse Recombinant Rcan2 Isoform 2 (from E. coli)Supplier: ProSci
10073-138EA 488.9 CAD10073-138
Mouse Recombinant Rcan2 Isoform 2 (from E. coli)
Proteins and Peptides
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).
This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
1X PBS containing 0.1% SDS
Store in working aliquots at -80°C. Avoid freeze/thaw cycles.