PD-1 Recombinant Protein, ProSci Inc

95-115
10073-140EA 397.55 CAD
10073-140
PD-1 Recombinant Protein, ProSci Inc
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens (3). Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases (4).

This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.

1X PBS containing 0.1% SDS

Store in working aliquots at -80°C. Avoid freeze/thaw cycles.
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