Anti-SET Rabbit Polyclonal Antibody

Supplier: Proteintech
55201-1-AP
10094-372EA 635.16 CAD
10094-372
Anti-SET Rabbit Polyclonal Antibody
Antibodies
SET, also named as IGAAD, I-2PP2A, TAF-I, IGAAD and PHAPII, belongs to the nucleosome assembly protein (NAP) family. It is a multitasking protein which involved in apoptosis, transcription, nucleosome assembly and histone binding. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. This antibody is specific to SET. It can recognize isoform1 and isoform2 of SET.

  • Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human Liver cancer, 1:20-1:200

Type: Primary
Antigen: SET
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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