Fibromodulin (FMOD), an extracellular matrix protein, belongs to the small leucine-rich proteoglycan family. Fibromodulin is a collagen-binding protein present in many types of connective tissues, e.g. cartilage, tendon, skin, sclera and cornea . It is involved in fibrillogenesis, cell adhesion, and cytokine activity modulation . Fibromodulin may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. The calculated molecular mass of fibromodulin is 43 kDa, extracellular fibromodulin appears as one single band of 59 kDa due to glycosylation .
Western Blot: Human Kidney, 1:200-1:2000; IHC: Human hepatocirrhosis Tissue, 1:20-1:200
Type: Primary
Antigen: Fibromodulin
Clonality: Monoclonal
Clone: 3E9D10
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human