Anti-OPTN Mouse Monoclonal Antibody [clone: 6C1H4]

Supplier: Proteintech
60293-1-IG
10091-592EA 635.16 CAD
10091-592
Anti-OPTN Mouse Monoclonal Antibody [clone: 6C1H4]
Antibodies
OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.

Western Blot: Human Heart Tissue, 1:500-1:5000

Type: Primary
Antigen: OPTN
Clonality: Monoclonal
Clone: 6C1H4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR