Anti-CUL4A Mouse Monoclonal Antibody [clone: 1A7F12]

Supplier: Proteintech
66038-1-IG
10085-348EA 635.16 CAD
10085-348
Anti-CUL4A Mouse Monoclonal Antibody [clone: 1A7F12]
Antibodies
Cullin proteins assemble a large number of RING E3 ubiquitin ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases, DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol, suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2. This antibody is specially against CUL4A, it will not cross-react with CUL4B.

Western Blot: Hela Cells, 1:200-1:2000; IHC: Human Heart Tissue, 1:20-1:200; IP: MCF-7 Cells, 1:200-1:2000

Type: Primary
Antigen: CUL4A
Clonality: Monoclonal
Clone: 1A7F12
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity:
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