IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.
Western Blot: Human Brain, 1:200-1:2000; IF: HepG2 Cells, 1:10-1:100; IHC: Human Brain Tissue, 1:20-1:200
Type: Primary
Antigen: IA-2/PTPRN
Clonality: Monoclonal
Clone: 1D3F5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG3
Reactivity: Human