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Anti-CD27 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: O323]

Supplier: Tonbo Biosciences
The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.

The O323 antibody may be used for analysis of CD27 expression on peripheral T cells, and is frequently used in combination with antibodies for IgD and IgM to distinguish naïve vs. memory B cell populations. For identification of Breg cells, this antibody has been used in combination with antibodies for CD25, CD1d, IL-10 and TGF-beta (Kessel et al. 2012. Autoimm. Rev. 11(9): 670-677). The antibody is also reported for cross-reactivity with Baboon, Cynomolgus and Rhesus CD27.

Type: Primary
Antigen: CD27
Clonality: Monoclonal
Clone: O323
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Baboon, Cynomolgus, Rhesus



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 Tests 35-0279-T100 10208-674 Each Retrieving Restricted
25 tests 35-0279-T025 10208-382 Each Retrieving Restricted
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SPECIFICATIONS

Antigen symbol CD27
Antigen name CD27 molecule
Reactivity Baboon, Cynomolgus Monkey, Human, Rhesus Monkey Rhesus Monkey, Baboon, Cynomolgus Monkey, Human
Conjugation FITC (Fluorescein Isothiocyanate)
Clonality Monoclonal
Antibody type Primary
Clone O323
Host Mouse
Isotype IgG1 kappa
Flow Cytometry Yes
Antigen synonyms S152. LPFS2, TNFRSF7, Tp55, CD27, T14, S152 TNFRSF7, Tp55, S152, CD27, T14, S152. LPFS2
Gene ID 939
Storage temperature 2-8°C protected from light
Tested Applications Flow Cytometry
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