This antibody is predicted to react with hamster, mouse and rat based on sequence homology. TOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.
Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry: 1:50-1:100
Type: Primary
Antigen: TOP2A (topoisomerase (DNA) II alpha 170kDa)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human