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Anti-SCUBE3 Rabbit Polyclonal Antibody

Supplier: Prosci
SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth.. SCUBE3 has been shown to be an endogenous TGF-beta ; receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta ; receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta ;1, VEGF, Snail, and Slug.

Type: Primary
Antigen: SCUBE3
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Size Supplier No. VWR Catalog Number Unit Price Quantity
20 µg 7003_S 10751-722 Each (20µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen symbol SCUBE3
Antigen name Signal peptide, CUB and EGF-like domain-containing protein 3
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoFluorescence Yes
Antigen synonyms CEGF3, SCUBE3, CUB and EGF-like domain-containing protein 3, Signal peptide
Concentration 1 mg/ml
Cross adsorption No
Immunogen SCUBE3 antibody was raised against a 15 amino acid synthetic peptide near the center of human SCUBE3.
Purification affinity chromatography purified via peptide column.
Form Liquid
Storage buffer PBS containing 0.02% sodium azide.
Storage temperature SCUBE3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Shipping temperature -20°C
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