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Anti-SHANK3 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SHANK3
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL 12143R-CY5.5 10225-158 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen symbol SHANK3
Antigen name SH3 And Multiple Ankyrin Repeat Domains 3
Reactivity Human, Mouse, Rat
Conjugation Cy5.5®
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms DEL22q13.3, Proline-rich synapse-associated protein 2, SPANK-2, PROSAP2, SCZD15, SH3 and multiple ankyrin repeat domains protein 3, PSAP2, Shank3, SHANK3, KIAA1650
Gene ID 85358
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 1165-1215/1741
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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