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Anti-SHC2 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SHC2
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL 12144R-CY5.5 10225-160 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen symbol SHC2
Antigen name SHC (Src Homology 2 Domain Containing) Transforming Protein 2
Reactivity Rat, Human, Mouse
Conjugation Cy5.5®
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms SHC-transforming protein 2, Src homology 2 domain-containing-transforming protein C2, SHC-transforming protein B, SH2 domain protein C2, SHC2, Protein Sck, SHCB
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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