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Anti-CYB5R3 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. A serine residue at position 117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It is not found in Caucasians, Asians, Indo-Aryans or Arabs. This difference seems to have no effect on the enzyme activity. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1), in which the enzyme is only deficient in erythrocytes with a mild cyanosis; type 2 (HM2), in which the enzyme is completely deficient; and type 3 (HM3), where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied by mental retardation and neurological impairment.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CYB5R3
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype:
Reactivity:



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL 12162R-CY5.5 10225-306 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen symbol CYB5R3
Antigen name Cytochrome b5 reductase 3
Reactivity Mouse, Rat, Human
Conjugation Cy5.5®
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms diaphorase 1 (NADH), C85115, WU:AL591952.1-003, Dia1, DIA1, diaphorase 1, NADH-cytochrome b5 reductase, 2500002N19Rik, WU:AL591952.1-002, Cyb5r3, 0610016L08Rik, WU:Cyb5r3, Dia-1, WU:AL591952.1-001
Gene ID 1727
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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