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Anti-MIB1 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
MIB1 is a 1006 amino acid E3 ubiquitin ligase that activates the Notch ligand, Delta. MIB1 ubiquinates Delta by binding to its intracellular domain, leading to the endocytosis and eventual degradation of the Delta receptor, which, paradoxically, results in the up-regulation of receptor activity and enhances Notch signaling. MIB1 also interacts with DAPK, a protein that plays an important role in the regulation of apoptosis. Ubiquination of DAPK leads to inhibition of caspase-dependent apoptosis, therefore it is likely that overexpression of MIB1 can lead to tumor growth. Although it seems to be widely expressed at low levels, MIB1 is expressed at highest concentrations in the CNS and ovary. Both DAPK and MIB1 are overexpressed in epileptic brain tissue, suggesting that they probably cooperate as regulators of neuronal death in epilepsy.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: MIB1
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL 12391R-CY5.5 10225-678 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen symbol MIB1
Antigen name Mindbomb E3 Ubiquitin Protein Ligase 1
Reactivity Human, Rat, Mouse
Conjugation Cy5.5®
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms MIB1, LVNC7, MIB, E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1, KIAA1323, DIP1, DIP-1, ZZZ6, ZZANK2
Gene ID 57534
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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