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Anti-NLE1 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: NLE1
Clonality: Polyclonal
Conjugation: Cy5.5®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL 12401R-CY5.5 10225-730 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen symbol NLE1
Antigen name Notchless Homolog 1
Reactivity Rat, Human, Mouse
Conjugation Cy5.5®
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms NLE 1, Notchless homolog 1, Notchless homolog 1 Drosophila, Notchless gene homolog, Nle, NLE1_HUMAN., FLJ10458, Notchless protein homolog 1
Gene ID 54475
Concentration 1 μg/μl
Cross adsorption No
Purification Purified by Protein A
Form liquid
Storage buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at 4°C for 12 months
Shipping temperature 4°C
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