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Specifications
- Antibody type:Primary
- Antigen name:Janus Kinase 2
- Clonality:Polyclonal
- Gene ID:3717
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:JAK2
- Conjugation:FITC (Fluorescein Isothiocyanate)
- ImmunoChemistry:Yes
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:JTK 10,JAK-2,JAK2,Janus Kinase 2,JTK10,JAK 2,Janus Activating Kinase 2
- Modification:phospho-Tyr1007/Tyr1008
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Cat. no.:10339-808
Specifications
About this item
JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of cytokine receptors; JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin; it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: JAK2
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat