Anti-NFATc2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Supplier: Bioss

BS-2669R-A647

10344-024EA 1226.38 CAD

10344-024

Anti-NFATc2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Antibodies

Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: NFATc2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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