Anti-CRK Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss
10346-978EA 1057.62 CAD
Anti-CRK Rabbit Polyclonal Antibody (Cy5®)
Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CRK
Clonality: Polyclonal
Conjugation: Cy5®
Host: Rabbit
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