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Anti-CRK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Anti-CRK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Catalog #: 10346-986
Supplier:  Bioss
Anti-CRK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Catalog #: 10346-986
Supplier:  Bioss
Price
$1,281.54
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Unit of Measure Each (100µl)
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    V-Crk Avian Sarcoma Virus Ct10 Oncogene Homolog
  • Clonality:
    Polyclonal
  • Gene ID:
    1398
  • Host:
    Rabbit
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Antigen symbol:
    CRK
  • Conjugation:
    HRP (Horseradish Peroxidase)
  • ImmunoChemistry:
    Yes
  • Size:
    100 µL
  • Western blot:
    Yes
  • Cross adsorption:
    No
  • Form:
    liquid
  • Antigen synonyms:
    proto-oncogene c-Crk,
    CRKII,
    p38,
    adapter molecule crk
  • Storage buffer:
    Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
  • Storage temperature:
    Store at 4°C for 12 months
  • Concentration:
    1 μg/μl
  • Shipping temperature:
    4°C
  • Purification:
    Purified by Protein A
  • Cat. no.:
    10346-986

Specifications

About this item

Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: CRK
Clonality: Polyclonal
Clone:
Conjugation: HRP (Horseradish Peroxidase)
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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