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Anti-LRDD Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Supplier: Bioss
BS-7615R-A350
The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: LRDD
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-7615R-A350 10465-852 Each (100µl) Retrieving Restricted

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SPECIFICATIONS

Antigen symbol LRDD
Antigen name Leucine-rich repeats And death Domain Containing
Reactivity Human, Rat, Mouse
Conjugation Alexa Fluor® 350
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen synonyms Leucine-rich repeats and death domain containing, DKFZp434D229, Leucine rich repeats and death domain containing, PIDD_HUMAN., MGC16925, p53-induced protein with a death domain, PIDD
Concentration 1 μg/μl
Cross adsorption No
Purification Purified by Protein A
Form liquid
Storage buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature Store at -20°C for 12 months
Shipping temperature 4°C
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