Order Entry
ContactUsLinkComponent
Anti-TP53 Rabbit Polyclonal Antibody
Anti-TP53 Rabbit Polyclonal Antibody
Catalog #: 10664-548
Supplier:  Bioss
Anti-TP53 Rabbit Polyclonal Antibody
Catalog #: 10664-548
Supplier:  Bioss
Price
$982.71
Log in for availability
Unit of Measure Each (100µl)
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
Restricted Products: To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:

  • • State issued document with your organization's Federal Tax ID Number
  • • State issued document with your organization's Resale Tax ID Number
  • • City or County issued Business License
  • • State Department of Health Services License
  • • Any other ID issued by the State that includes the business name & address

* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Tumor Protein p53
  • Clonality:
    Polyclonal
  • Gene ID:
    7157
  • Host:
    Rabbit
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Antigen symbol:
    TP53
  • Conjugation:
    Unconjugated
  • ImmunoChemistry:
    Yes
  • Size:
    100 µg
  • Western blot:
    Yes
  • Cross adsorption:
    No
  • Form:
    liquid
  • Antigen synonyms:
    Tumor suppressor p53,
    Cellular tumor antigen p53,
    TP53,
    Antigen NY-CO-13,
    Phosphoprotein p53
  • Storage buffer:
    Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
  • Storage temperature:
    Store at –20 °C for 12 months
  • Concentration:
    1 μg/μl
  • Shipping temperature:
    4°C
  • Purification:
    Purified by Protein A
  • Cat. no.:
    10664-548

Specifications

About this item

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: TP53
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

Customers Who Bought This Also Bought