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Specifications
- Antibody type:Primary
- Antigen name:B-cell linker
- Clonality:Polyclonal
- Gene ID:29760
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:BLNK
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Western blot:Yes
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Src homology 2 domain-containing leukocyte protein of 65 kDa,B-cell adapter containing a Src homology 2 domain protein,B cell adaptor containing SH2 domain,B cell linker protein,cytoplasmic adapter protein,SLP-65,B-cell activation,LY57,AGM4,B-cell adapter containing a SH2 domain protein,BLNK-S,bca,B-cell linker protein,SLP65,BASH,Src homology [SH2] domain-containing leukocyte protein of 65 kD
- Modification:Tyr84
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Cat. no.:10494-504
Specifications
About this item
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200
Type: Primary
Antigen: BLNK
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat