Human Recombinant sCD30 (from CHO Cells)Supplier: PeproTech
450-42-250UG 450-42-500UG 450-42-1MG 450-42-10UG 450-42-100UG 450-42-50UG
10771-104EA 922.5 CAD10771-104 10771-106 10771-108 10771-098 10771-102 10771-100
Human Recombinant sCD30 (from CHO Cells)
Proteins and Peptides
CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-κB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, and cell division. Certain diseases, including Hodgkin’s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. Recombinant Human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His-Tag. The calculated molecular weight of Recombinant Human sCD30 Ligand is 21.3 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.