Mouse Recombinant GDNF (from E. coli)Supplier: PeproTech
450-44-2UG 450-44-1MG 450-44-250UG 450-44-50UG 450-44-100UG 450-44-500UG 450-44-10UG
10771-110EA 150.18 CAD10771-110 10771-122 10771-118 10771-114 10771-116 10771-120 10771-112
Mouse Recombinant GDNF (from E. coli)
Proteins and Peptides
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.