Human Recombinant HB-EGF (from E. coli)Supplier: PeproTech
100-47-500UG 100-47-1MG 100-47-250UG 100-47-100UG 100-47-50UG 100-47-10UG
10772-218EA 1688.73 CAD10772-218 10772-220 10772-216 10772-214 10772-212 10772-210
Human Recombinant HB-EGF (from E. coli)
Proteins and Peptides
HB-EGF is an EGF-related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells, and vascular SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.