Human Recombinant p16-INK4a (from E. coli)Supplier: PeproTech
110-02-100UG 110-02-1MG 110-02-5UG 110-02-500UG 110-02-20UG
10772-328EA 1500.98 CAD10772-328 10772-334 10772-324 10772-332 10772-326
Human Recombinant p16-INK4a (from E. coli)
Proteins and Peptides
p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin-dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas, as well as in certain other types of cancer. Recombinant Human p16-INK4a is a 16.5 kDa protein containing 156 amino acid residues.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.