Human Recombinant Lin28-TAT (from E. coli)Supplier: PeproTech
110-06-100UG 110-06-25UG 110-06-250UG 110-06-1MG 110-06-500UG 110-06-5UG
10772-376EA 1126.37 CAD10772-376 10772-374 10772-378 10772-382 10772-380 10772-372
Human Recombinant Lin28-TAT (from E. coli)
Proteins and Peptides
Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors. Lin28 is found abundantly in embryonic stem cells (ESCs), and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation, a necessary step in the differentiation of stem cells and certain cancer cell lines. Together with Sox2, Oct4, and Nanog, Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state. Lin28 and other regulatory proteins can be introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary, as well as transformed, cells. Recombinant Human Lin28-TAT is a 24.4 kDa protein containing 222 amino acid residues, including a 13-residue C-terminal TAT peptide.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.