Human Recombinant Noggin (from HEK293 cells)Supplier: PeproTech
120-10C-5UG 120-10C-20UG 120-10C-50UG 120-10C-500UG 120-10C-250UG 120-10C-100UG
10772-454EA 155.84 CAD10772-454 10772-456 10772-458 10772-464 10772-462 10772-460
Human Recombinant Noggin (from HEK293 cells)
Proteins and Peptides
Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.