Human Recombinant Nanog-TAT (from E. coli)Supplier: PeproTech
120-21B-20UG 120-21B-5UG 120-21B-100UG 120-21B-250UG 120-21B-1MG 120-21B-500UG
10772-590EA 366.09 CAD10772-590 10772-588 10772-592 10772-594 10772-598 10772-596
Human Recombinant Nanog-TAT (from E. coli)
Proteins and Peptides
Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, that helps maintain pluripotency and self renewal via a STAT3-independent pathway. The introduction of nanog, along with Sox2, Oct4, and Lin28, into primary human fibroblasts was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology and gene expression. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors into primary, as well as transformed, cells. Recombinant Human Nanog-TAT is a 36.1 kDa protein, which is synthesized as a 304 amino acid polypeptide plus a 13- residue C-terminal TAT peptide.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.