Human Recombinant sTNF (from E. coli)Supplier: PeproTech
310-12-100UG 310-12-20UG 310-12-1MG 310-12-250UG 310-12-5UG 310-12-500UG
10774-214EA 1126.37 CAD10774-214 10774-212 10774-220 10774-216 10774-210 10774-218
Human Recombinant sTNF (from E. coli)
Proteins and Peptides
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α, but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α-induced activities by acting as a decoy receptor. The human TNFRII gene encodes for a 461 amino acid type I transmembrane protein, which contains a 22 amino acid signal sequence, a 235 amino acid extracellular domain, a 30 amino acid transmembrane domain, and a 174 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type II is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine-rich, ligand binding portion of the extracellular domain of the TNFRII protein.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.