Mouse Recombinant GDF-5 (from E. coli)Supplier: PeproTech
315-24-50UG 315-24-10UG 315-24-250UG 315-24-1MG 315-24-100UG 315-24-500UG
10774-342EA 366.09 CAD10774-342 10774-340 10774-346 10774-350 10774-344 10774-348
Mouse Recombinant GDF-5 (from E. coli)
Proteins and Peptides
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino acid polypeptide chains (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 348 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Murine GDF-5 (BMP-14/CDMP-1) is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.