Human Recombinant Adiponectin (from Hi-5 Insect cells)Supplier: PeproTech
450-24-5UG 450-24-25UG 450-24-100UG 450-24-500UG 450-24-250UG 450-24-1MG
10774-664EA 150.18 CAD10774-664 10774-666 10774-668 10774-672 10774-670 10774-674
Human Recombinant Adiponectin (from Hi-5 Insect cells)
Proteins and Peptides
Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant Human Adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions. The calculated molecular weight of Recombinant Human Adiponectin is 25.9 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.